Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Age, as well as male gender, results in a greater rate of death related to CRC. Encompassing all ages and genders, it is estimated that nearly 53,000 people in the United States will die in 2022 due to CRC.1

All Cancers in America

~1.9 MILLION new cancer cases expected1

~609,000 cancer deaths expected1

Predicted Cancer Deaths 20221

Table of predicted cancer deaths 2022Rounded to the nearest 10

52,580 colorectal cancer deaths expected in 2022, making it the 2nd leading cause of cancer mortality in the US in both sexes combined1

One study found that among those who died from CRC, 76% were not up to date with screening.2,a Learn more about the value of timely screening

Colorectal Cancer Deaths by Age and Gender

  Estimated Number of Colorectal Cancer Cases and Deaths in the
US in 2020 By Age3,b
0-49 years 17,930 11,540 6390 3640
50-64 years 50,010 32,290 17,720 13,380
65+ years 80,010 60,780 19,230 36,180
All ages 147,950 104,610 43,340 53,200
  • As with most cancers, the risk of CRC and CRC-related death increases with age3,4
  • Learn more about CRC incidence


Chart of CRC deaths over time

  • Cancer deaths have been generally decreasing since their peak in 1991, largely related to improvements in early detection and treatment1
  • Death due to CRC has decreased by 53% since 1980 in males and by 59% since 1969 in females1


Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022;72:7-33.

Doubeni CA, Fedewa SA, Levin TR, et al. Modifiable failures in the colorectal cancer screening process and their association with risk of death. Gastroenterol. 2019;156(1);63-74.

Siegel RL, Miller KD, Goding Sauer A, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145-164.

American Cancer Society. Colorectal cancer facts & figures 2020-2022. Atlanta: American Cancer Society; 2020.



Data are from a retrospective cohort study of patients in the Kaiser Permanente Northern and Southern California systems (55-90 years old) who died of CRC from 2006 through 2012 and had at least 5 years of enrollment before diagnosis. Data were compared to a matched cohort of cancer-free patients in the same system. Of 1750 CRC deaths identified, 75.6% occurred in patients who were not up-to-date with CRC screening.

Estimates are rounded to the nearest 10 and exclude in situ carcinoma. Values are based on estimates for 2020. In 2020, the total deaths predicted to be a result of colorectal cancer was 53,200.

Deaths for colon and rectal cancers are combined because a large number of rectal cancer deaths are misclassified as colon.

Rates are adjusted to the 2000 US standard population. Due to changes in International Classification of Diseases (ICD) coding, numerator information for mortality has changed over time.

Last Updated: 3/1/2022