• Models are an imperfect yet important tool to help quantify and articulate the value of a healthcare intervention when research is not feasible to produce desired data.1 Cancer Intervention and Surveillance Modeling Network (CISNET) models, primarily CRC-SPIN, are used in colorectal cancer (CRC) screening decision-making.2

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  • The Colorectal Cancer-Adenoma Incidence and Mortality (CRC-AIM) model is a microsimulation model based on the CISNET model and Colorectal Cancer-Simulated Population model for Incidence and Natural history (CRC-SPIN) and includes natural history and colorectal cancer (CRC) screening components.3 CRC-AIM has been cross-validated against CISNET models.3

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Learn more about the full Indications/Contraindications for the mt-sDNA test.   Please see complete prescribing information for Cologuard in the Cologuard Clinician Brochure


MapleHealth workshop on Health Economic and Outcomes Research, November 8, 2019

CISNET modeling approach. National Cancer Institute website. Accessed April 22, 2023. https://cisnet.cancer.gov/modeling/index.html.

Piscitello A, Saoud L, Fendrick AM,  et al. Estimating the impact of imperfect adherence to stool-based colorectal cancer screening strategies on comparative effectiveness using the CRC-AIM microsimulation model. PLoS One. 2020;15(12):e0244431.


Last Updated: 04/22/2023