• Models are an imperfect yet important tool to help quantify and articulate the value of a healthcare intervention when research is not feasible to produce desired data.1 Cancer Intervention and Surveillance Modeling Network (CISNET) models, primarily CRC-SPIN, are used in colorectal cancer (CRC) screening decision-making.2

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  • The Colorectal Cancer-Adenoma Incidence and Mortality (CRC-AIM) model is a microsimulation model based on the CISNET model and Colorectal Cancer-Simulated Population model for Incidence and Natural history (CRC-SPIN) and includes natural history and colorectal cancer (CRC) screening components.3 CRC-AIM has been cross-validated against CISNET models.3

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Learn more about the full Indications/Contraindications for the mt-sDNA test. Please see complete prescribing information for mt-sDNA in the Cologuard Physician Brochure.

References

 MapleHealth workshop on Health Economic and Outcomes Research, November 8, 2019.

CISNET modeling approach. National Cancer Institute website. Accessed December 10, 2021. https://cisnet.cancer.gov/modeling/index.html.

Piscitello A, Saoud L, Fendrick AM,  et al. Estimating the impact of imperfect adherence to stool-based colorectal cancer screening strategies on comparative effectiveness using the CRC-AIM microsimulation model. PLoS One. 2020;15(12):e0244431.

Last Updated: 3/1/2022

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