For providers
Clinical evidence
Rigorous testing for results you can trust
The OncoExTra® test is validated to profile tumor DNA and RNA for actionable variants, thus providing all-encompassing insights that can affect treatment guidance.
Analyze all protein-coding genes. All in a single test.
Analyze all protein-coding genes. All in a single test.
Traditional profiling methods examine only small, fixed panels, leaving unknowns in treatment decisions. Using whole-exome, whole-transcriptome sequencing across nearly 20,000 genes, the OncoExTra test ensures that all possible protein-coding genes are sequenced and evaluated for actionable variants.*,1
Sequencing that isolates what’s important
Every person has unique genetic variants in their DNA. Patient-matched tumor-normal sequencing is the process of identifying those normal germline DNA variants in a patient’s blood sample, and then subtracting them from those found in the tumor sample to isolate only somatic, actionable variants.2 Germline subtraction using patient-matched tumor-normal sequencing helps to:
Limit false positives by ruling out benign variants in a patient’s tumor sample1
Identify the actionable somatic variants most likely to respond to therapy1
Reduce the overestimation of tumor mutational burden (TMB)1,2
Actionable variants have been found across various types of solid tumors1
98%
of colorectal samples
(164/167)
96%
of lung samples
(53/55)
96%
of bladder samples
(25/26)
93%
of breast samples
(80/86)
Innovative and insightful. That’s the power of the OncoExTra test.
OncoExTra validation summary
Analytic validation and clinical utilization of the comprehensive genomic profiling test.
The impact of DNA and RNA testing on patient care
Analyzed data from over 10,000 solid tumor samples from patients with advanced cancer found that more than 90 percent contained genomic changes that could guide treatment.
Next-generation RNA and DNA sequencing
A series of seven cases showcasing the value of comprehensive genomic sequencing to maximize the identification of clinically actionable alterations in advanced cancer patients.
Simple ordering and result tracking. All in one hub.
Quickly place and manage test orders, track results, and access easy-to-interpret reports on the Exact Sciences Provider Hub.
Have questions?
If you have any additional questions about the evidence and impact of OncoExTra on patient outcomes, call us at 1 866-662-6897 .