- Spending shown represents cancer-attributable costs calculated as the average monthly difference in costs between CRC cases minus their matched controls multiplied by 12 and inflated to 2014 dollars. Medicare costs include Medicare payments and patient's responsibility. The first 12 months after diagnosis were described as the initial phase.5 Values have been adjusted to 2025 US dollars using an average inflation rate of 2.84% and cumulative inflation of 36.06%.
- All positive results on non-colonoscopy screening tests should be followed up with timely colonoscopy.6
- For adults at high risk, testing may be more frequent and should be discussed with a healthcare provider.7
- Per CMS coverage.6
- Exact Sciences' estimate based on historical patient billing. Rate of coverage varies by state and region. Exceptions for coverage may apply; only your patients' insurers can confirm how Cologuard would be covered.
- The USPSTF-recommended screening frequency for sDNA-FIT is every 1 to 3 years.8 The ACS recommended screening interval for mt-sDNA is every 3 years.6 Guidelines may refer to the Cologuard test by different names, including mt-sDNA, FIT-fecal DNA, sDNA, and sDNA-FIT.
- sDNA (i.e, Cologuard test) is one of the methods permitted for patients at average risk aged 45 to 75 years as part of the National Committee for Quality Assurance's (NCQA) HEDIS® quality measures for colon cancer screening. Third parties creating guidelines and quality measures do not specifically endorse commercial products, and inclusion in same does not imply otherwise.17 HEDIS® is a registered trademark of the National Committee for Quality Assurance (NCQA).
- Siegel RL, Wagle NS, Star J, et al. Colorectal cancer statistics, 2026. CA Cancer J Clin. 2026;e70067. doi:10.3322/caac.70067
- 80% in our community. American Cancer Society National Colorectal Cancer Roundtable. Updated July 31, 2025. Accessed June 25, 2026. https://nccrt.org/our-impact/80-in-every-community/
- Ebner DW, Kisiel JB, Fendrick AM, et al. Estimated average-risk colorectal cancer screening-eligible population in the US. JAMA Netw Open. 2024;7(3):e245537.
- Itzkowitz SH. Incremental advances in excremental cancer detection tests. J Natl Cancer Inst. 2009;101(18):1225-1227.
- Mariotto AB, Warren JL, Zeruto C, et al. Cancer-attributable medical costs for colorectal cancer patients by phases of care: what is the effect of a prior cancer history? J Natl Cancer Inst Monogr. 2020(55):22-30. doi:10.1093/jncimonographs/lgz032
- Wolf AMD, Hoffman RM, Walter LC, et al. Colorectal cancer screening: An update to the American Cancer Society guideline, 2026. CA Cancer J Clin. 2026. 2026;e70083. https://doi.org/10.3322/caac.70083
- American Cancer Society. Colorectal Cancer Facts & Figures 2020-2022. Atlanta: American Cancer Society; 2020.
- Colorectal cancer screening tests. American Cancer Society. Updated February 28, 2025. Accessed September 1, 2026. https//www.cancer.org/cancer/types/colon-rectaI-cancer/detection-diagnosis-staging/screening-tests-used.htmI
- SimpleScreen CRC Provider Brochure. Freenome LLC. Brisbane, CA.
- HEDIS® Measurement Year 2022 Volume 2: Technical Update. National Committee for Quality Assurance (NCQA). March 31, 2022. Accessed September 1, 2026. https://www.ncqa.org/wp-content/uploads/2022/03/MY-2022-Vol-2-Technical-Update.pdf
- FAQ Directory. HEDIS. National Committee for Quality Assurance. Accessed September 1, 2026. https://www.ncqa.org/hedis/faq/
- Data on file for coverage. Market Access. 2025. Exact Sciences Corporation. Madison, WI.
- Insurance coverage for colorectal cancer screening. American Cancer Society. Updated May 20, 2026. Accessed September 1, 2026. https://www.cancer.org/cancer/types/colon-rectal-cancer/detection-diagnosis-staging/screening-coverage-laws.html
- ColoSense® Clinician Brochure. St Louis, MO. Geneoscopy Inc.
- American Cancer Society. Colorectal cancer early detection, diagnosis, and staging. January 20, 2024. Accessed September 1, 2026. https://www.cancer.org/content/dam/CRC/PDF/Public/8606.00.pdf
- Estes C, Dehghani M, Ozbay AB, et al. Clinical, social, and economic impacts of colorectal cancer screening with the multitarget stool-DNA test: 10-year experience—a simulated study. medRxiv preprint. 2024. doi: https://doi.org/10.1101/2024.08.07.24311643
- NCQA updates HEDIS measure for colorectal cancer screening. Healio. October 6, 2016. Accessed September 1, 2026. https://www.healio.com/news/gastroenterology/20161006/ncqa-updates-hedis-measure-for-colorectal-cancer-screening
- Colorectal Cancer Screening (COL-E). National Committee for Quality Assurance (NCQA). Accessed September 1, 2026. https://www.ncqa.org/report-cards/health-plans/state-of-health-care-quality-report/colorectal-cancer-screening-col-e/
ACS=American Cancer Society; DNA=deoxyribonucleic acid; FDA=US Food and Drug Administration; FIT=Fecal Immunochemical Test; FOBT=Fecal Occult Blood Test; HEDIS=Healthcare Effectiveness Data and Information Set; mt-sDNA=multitarget stool DNA; RNA=ribonucleic acid; USPSTF=United States Preventive Services Task Force.