For providers
Oncotype DX Breast Recurrence Score® Test

Guidance to help inform treatment decisions 

The Oncotype DX Breast Recurrence Score test provides personalized genomic insights for patients with early-stage HR+, HER2- breast cancer.1-6,16,17
An Exact Sciences lab technician opening a test box.
For patients with HR+, HER2- breast cancer1-6,16,17
Sample taken from existing tumor tissue
Aids in treatment decision-making
An Exact Sciences lab technician opening a test box.
A lab technician examining a test sample.

The only test proven to predict the likelihood of chemotherapy benefit1,2,8

3 ways this test can help

Supporting you and your patients in making more informed treatment decisions by understanding their unique tumor biology, their risk of recurrence, and the potential magnitude of chemotherapy benefit.1-6,16,17

The Breast Recurrence Score® test

  • Uses tissue obtained at the time of core biopsy or surgical excision7
  • Assesses the expression of 21 genes3
    • 16 cancer-related genes
    • 5 reference genes
  • Uses reverse transcription polymerase chain reaction (RT-PCR) to analyze tumor RNA3

A genomic assessment

  • Includes the estimated risk of distant recurrence with endocrine therapy alone2,3,4,5,16,17
  • Helps predict the benefit of adding chemotherapy to endocrine therapy1,2,8

Quantitative single-gene scores

  • Quantitative estrogen receptor (ER) score helps assess the magnitude of hormonal therapy benefit3,9,18,19
  • Provides additional supporting information, such as progesterone receptor (PgR) and HER2 scores3,9,18,19
A doctor and nurse talking in front of a computer monitor.
Science you can trust

Backed by a solid body of clinical evidence

5 key validation studies1-5
1.9+ million patients10
Consistent results1-5

Included in major international breast cancer treatment guidelines

Based on a significant body of clinical evidence, including level IA and IB, the Oncotype DX Breast Recurrence Score test has been incorporated into multiple clinical practice guidelines, recommendations, and consensuses including NCCN, ASCO®, St. Gallen, and ESMO, recommended by NICE for reimbursement coverage, and incorporated into the AJCC Cancer Staging Manual (8th edition) for assignment of Prognostic Stage group.8,11-13,14-16*

*National Comprehensive Cancer Network and NCCN are registered trademarks of the National Comprehensive Cancer Network.

A woman holding up a large card displaying her test results.

Not all genomic tests are created equal

The Oncotype DX Breast Recurrence Score test is the only genomic assay proven to be both prognostic of distant recurrence risk and predictive of chemotherapy benefit. No other genomic test or risk assessment tool provides similar predictive insights.1-6, 8
Two women hugging and smiling.

Is your patient eligible?

The Oncotype DX Breast Recurrence Score test is appropriate for patients who are:1-6,16,17

  • Recently diagnosed with invasive breast cancer
    • Anatomic stage I, II, or IIIa
    • Hormone receptor-positive (HR+)
    • Human epidermal growth factor receptor 2-negative (HER2-)
    • Node negative (N0) or node positive (N1mic or N1) 
  • Medically eligible for chemotherapy



NOTE: Your patients diagnosed with noninvasive breast cancer, ductal carcinoma in situ (DCIS), may be eligible for the Oncotype DX Breast DCIS Score® test.

The Breast Recurrence Score test is well covered

86% of patients paid $0 91% paid less than $100*

*This calculation includes patients with Medicare, Medicare Advantage, Medicaid, Managed Medicaid, and commercial insurance. Patients with high-deductible plans may receive a bill for most or all the cost of the Breast Recurrence Score test if they have not satisfied their deductible. The numbers cited are based on historical patient billing data from 1/2/2024 to 12/31/2024. Rates of coverage vary by state and region. Exceptions for coverage may apply. Exact Sciences strongly encourages your patient to contact their insurer with questions about Oncotype DX Breast Recurrence Score test coverage.
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Ordering a test for your patients is fast and easy

Order tests, access results, and receive updates through our Provider Hub.

Explore other testing solutions

We offer a range of tests designed to support your breast cancer patients.

Oncotype DX Breast DCIS Score® test

A tumor-tissue early-stage DCIS breast cancer test that shows how likely breast cancer will return and possible radiation benefit
Cancer type:
Breast
Test type:
Treatment guidance
Treatment guidance tests show how likely cancer might come back and/or how beneficial specific treatments might be to help inform care decisions.
Sample type:
Tumor tissue

Have questions?

Call us at 1 866-662-6897.