For providers
Riskguard® Hereditary Cancer Risk Test

The Riskguard® test helps you help your patients

The Riskguard® test is an assessment tool that can help uncover hereditary cancer risk. The actionable results can help you better understand your patients’ risk level and management options supporting personalized care.
A doctor talking with a patient.
Inspect 56 genes across 10 common cancer types
Testing done on blood or saliva samples
Gauge cancer risk to inform treatment and prevention
A doctor talking with a patient.

How can the Riskguard test help?

Parents with two small children sitting on a couch and talking to a woman.

Patients without cancer

The Riskguard test helps inform the risk stratification for patients who have a family history of cancer by identifying variants in clinically actionable cancer-associated genes, from which you can form a customized path.

Customize a prevention path

  • Lifestyle changes
  • Screening programs
  • Risk-reducing medication
  • Risk-reducing surgeries
A mother hugging her daughter by a window.

Patients with cancer

The Riskguard test can assist with informing an individualized plan for your patients who have been diagnosed with cancer. Knowing about certain gene variants can help you select optimal treatment.1-6

Inform optimal treatment

  • Surgical options
  • Increased surveillance
  • Targeted therapies

More ways to personalize patient care

Pair the Riskguard test with our Oncotype DX Breast Recurrence Score® test to help inform a more comprehensive treatment plan for newly diagnosed ER+/HER2- breast cancer.

Add the Riskguard test with our OncoExTra® genomic profiling test to enable more patients with advanced or metastatic cancer to be considered for targeted therapies.

The Riskguard test checks for genes across 10 cancer types

Colorectal ​ ​ ​ ​Breast ​ ​ ​ ​Prostate ​ ​ ​ ​Pancreatic ​ ​ ​ ​Ovarian ​ ​ ​ ​Endometrial ​ ​ ​ ​Skin ​ ​ ​ ​Gastric ​ ​ ​ ​Kidney ​ ​ ​ ​Endocrine

We keep it simple and actionable

We want our results to be simple yet powerful. That's why we only report on variants in genes you can do something about based on guidelines and published literature. We provide easy-to-understand results that providers and patients can use for personalized care planning.

Negative sample report (PDF)
Positive BRCA2 sample report (PDF)
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Complete access to our premium customer support before, during, and after testing

On-demand customer care

Call our customer care team for general questions. You can request Riskguard test kits, and ask about billing, ordering, and how to access results.

Call +1 866-662-6897

Genetic support for your patients

Our customer care team can help answer your patients’ questions about the Riskguard test and the testing process. We can also connect them with an independent genetic counselor,* who will take a more detailed family history and provide more in-depth information.

Genetic support for you

Ask customer care to connect you with one of our genetic counselors for an in-depth consult. We can help you understand and interpret Riskguard test results, including medical management options for your patient.

Patient education on demand

Want to help your patients learn about the Riskguard test? Genetic counselor Brandie Leach breaks down who the test is for, what the testing process is like, and how the results could inform your risks.

Billing is easy when you have a support team like ours

  • Coverage for eligible patients including Medicare and commercial insurance
  • Specialized support for billing insurance and prior authorization
  • Flexible payment options for patients
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Let's get started

Step 1

Request Riskguard test kits

The Riskguard test collection kit box sitting on a table.

Call customer care to request Riskguard test kits. We can send blood or saliva test kits right to your office, or we can send a convenient at-home saliva test kit directly to your patient's address.†

Call +1 866-662-6897

Step 2

Submit lab order

A screenshot showing the Riskguard test ordering process.

It’s easy to submit an order for the Riskguard test right on our Exact Sciences Provider Hub.

Submit order
New York provider statement (PDF)

If you prefer not to order on our Provider Hub, you can download the test requisition form (PDF) and fax it to 1-715-406-4175 once completed. If you are collecting a sample in clinic, include a copy of the order form in the specimen kit.

Step 3

Access results

A closeup of a doctor using a tablet.

You can view your patients’ results on our Exact Sciences Provider Hub. Patients can access their results with their own Exact Sciences account. If they have additional questions, we can connect them to an independent genetic counselor.*

Access patient results

Provider resources

Riskguard + Oncotype DX® case study

PDF
Adding the Riskguard test to the Oncotype DX test can give you powerful information.

Riskguard + OncoExTra® case study

PDF
See how adding the Riskguard test to the OncoExTra test can give you more answers.

Patient education video

Video
Learn more about how the Riskguard test can help guide treatment and prevention.

Billing and coverage info card

PDF
We're here to help. Our support team can help your patients navigate the insurance coverage process.

Gene list

PDF
Riskguard is a multigene test that may impact clinical decision-making in common cancer types.

Patient identification resources

PDF
See which risk factors and diagnoses make the Riskguard test a fit for your patients with cancer.

Frequently asked questions

How much does this test cost?
Most insurance plans cover eligible patients including Medicare and commercial insurance. Out-of-pocket (OOP) costs for the test, if any, are determined by the patient’s insurance company. They may have co-pay, co-insurance, deductible, or non-covered charges as determined by the individual’s plan. We offer flexible payment options to help with their cost.  
What is the turnaround time (TAT)?
You should receive patient results in approximately 14 to 21 days‡ of sample submission. 
What if I don’t have access to a genetic counselor?
We’ll get you in touch with our genetic counselors who can help you assess your patient’s risk, interpret their results, and review medical management options. Our customer care team can help patients learn about the Riskguard test, explore the testing process, and understand possible results and outcomes or connect them to an independent genetic counselor.
Are your lab and test New York state certified?
Yes. New York State Approval Project ID 93819. For more information visit Wadsworth Center approved LDTs.

We're here for you

With questions about ordering the Riskguard test, insurance billing and payment options, checking results, or getting connected with a genetic counselor, call us at +1 866-662-6897 or email us at riskguard@exactsciences.com.

References

  1. There may be a patient cost associated with independent genetic counseling services.
  2. Riskguard test kits are provided at no charge and are to be used only with the Riskguard test.
  3. Data on file

  1. Geyer CE Jr, Garber JE, Gelber RD, et al. OlympiA Clinical Trial Steering Committee and Investigators. Overall survival in the OlympiA phase III trial of adjuvant olaparib in patients with germline pathogenic variants in BRCA1/2 and high-risk, early breast cancer. Ann Oncol. 2022;33(12):1250-1268.
  2. Hussain M, Mateo J, Fizazi K, et al. PROfound Trial Investigators. Survival with olaparib in metastatic castration-resistant prostate cancer. N Engl J Med. 2020;383(24):2345-2357.
  3. Golan T, Hammel P, Reni M, et al. Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer. N Engl J Med. 2019;381:317-327.
  4. Ledermann J, Harter P, Gourley C, et al. Olaparib maintenance therapy in patients with platinum-sensitive relapsed serous ovarian cancer: A preplanned retrospective analysis of outcomes by BRCA status in a randomised phase 2 trial. Lancet Oncol. 2014;15:852-861.
  5. Domchek SM, Friebel TM, Singer CF, et al. Association of risk-reducing surgery in BRCA1 or BRCA2 mutation carriers with cancer risk and mortality. JAMA. 2010;304(9):967-975.
  6. Ladabaum U, Wang G, Terdiman J, et al. Strategies to identify the Lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. Ann Intern Med. 2011;155(2):69-79.
The Exact Sciences Riskguard test was developed, and its performance characteristics validated by an Exact Sciences laboratory following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. The test is performed in Marshfield, WI at PreventionGenetics LLC, a wholly owned subsidiary of Exact Sciences. PreventionGenetics is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing. It has not been cleared or approved by the US Food and Drug Administration or other notified regulatory authority. Genomic Health, Inc., an Exact Sciences company, is the billing entity for the Riskguard test.