Riskguard™ Hereditary Cancer Test is a 32-gene Next-Gen Sequencing test for those who want to understand their risk of developing inherited forms of cancer, why cancer may be common in their family, and their screening options.

Understanding this can help physicians create personalized health care plans following a cancer diagnosis.

Exact Sciences has joined forces with PreventionGenetics to add Riskguard—a hereditary multi-cancer panel—to our growing portfolio of oncology tests throughout the care continuum.

For Providers

For Patients

Inform Personalized Treatment By Uncovering Hereditary Cancer Risk

Identify germline variants that may impact clinical decision-making in breast, prostate, colorectal, ovarian, endometrial, pancreatic, gastric, and melanoma cancers.



Provides an easy-to-understand report that includes both the individual and familial risks associated with a patient’s result, including potential care options for treatment discussions


Analyzes and focuses on 32 high-risk, clinically actionable genes informed by professional guidelines for patient management1


Offers access to genetic counseling and world- class customer service to physicians, patients, and family members for a smooth experience

Utilize Riskguard’s comprehensive gene panel

Gain a more comprehensive view into patients’ conditions and their susceptibility to certain cancer risk by using a 32-gene hereditary multi-cancer gene panel.

How To Order Riskguard

  1. Download Order form
  2. Collect blood, saliva, or buccal sample and send to PreventionGenetics
  3. Receive results via FAX, email, or portal in approximately 18 days2

Frequently Asked Questions

Contact Us

With questions about the test, order form, kits, or patient results Call us at 855-669-4579

To learn more about genetic counseling Call us at 855-669-4579

For help navigating the insurance and billing process, see our Billing and Coverage page

Know your inherited cancer risk so you can be proactive about your health

If you have already been diagnosed with cancer, knowing your risk gives healthcare providers the opportunity for more personalized treatment options. If you have a gene variant known to increase the risk of getting cancer, knowing your risk can guide a more specific cancer screening schedule.

Riskguard can detect gene variants in these cancers: breast, prostate, colorectal, ovarian, endometrial, pancreatic, gastric, and melanoma.

How does testing help my family?

Once one person in a biological family is found to have a gene variant that is associated with a higher risk of getting cancer, other family members can benefit from that information.

Family members can receive the Riskguard test to see if they carry the same gene variant, and their chances of developing cancer in their lifetime, and can speak with a healthcare provider about cancer screening options.

What do the results mean?

Riskguard test results are designed to be simple and easy-to-understand.


A pathogenic gene variant is found. This result does not mean you'll develop cancer. It does mean that your risk for inherited forms of cancer is higher than average.


A pathogenic gene variant is not found. This result means that your risk for inherited forms of cancer should be considered in the context of your personal or family history.


At least one genetic mutation was found, but it is unclear if this change causes an increased risk for an inherited cancer.

Make a plan with your doctor

If you learn that you’re at an increased risk for cancer, speak with your doctor or a genetic counselor to create a plan. This may include earlier screening, medications that can help prevent cancer, and other preventive options.1

How does the testing process work?


A blood, saliva, or buccal sample is taken and sent to the lab at PreventionGenetics for genetic analysis.


If required by your insurance, we will contact your health plan to request coverage for testing. In some cases, your healthcare provider may request that you speak with a genetic counselor prior to testing.


The hereditary multi-cancer test is performed, and results will be sent to your doctor.


Your healthcare provider will review the Riskguard test results with you. Your healthcare provider may request that you speak with a Genetic Counselor to discuss your results and answer any questions you may have about your family members being tested.

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1. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. V2.2022 and Genetic/Familial High-Risk Assessment: Colorectal Cancer. V2.2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed August 1, 2022. To view the most recent and complete version of the guidelines, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
2. Data on File.