Riskguard

Riskguard™ Hereditary Cancer Test is a 32-gene Next Generation Sequencing test for those who want to understand their risk of developing inherited forms of cancer, why cancer may be common in their family, and their screening options.

Understanding this can help physicians create personalized health care plans following a cancer diagnosis.

Exact Sciences has joined forces with PreventionGenetics to add Riskguard—a hereditary multi-cancer panel—to our growing portfolio of oncology tests throughout the care continuum.

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INSURANCE COVERAGE

Riskguard is covered for 96% of patients with insurance. ¹

Financial assistance is available for patients with and without insurance. Patients eligible for financial assistance will have no cost for testing.*

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For Providers

For Patients

Inform Personalized Treatment By Uncovering Hereditary Cancer Risk

Identify germline variants that may impact clinical decision-making in breast, prostate, colorectal, ovarian, endometrial, pancreatic, gastric, and melanoma cancers.

THE RISKGUARD™ CANCER PANEL

INDIVIDUALIZED REPORT

Provides an easy-to-understand report that includes both the gene specific and familial risks associated with a patient’s result, including potential care options for treatment discussions

Download a sample patient report

CLINICALLY ACTIONABLE

Analyzes and focuses on 32 clinically actionable genes informed by professional guidelines for patient management¹

DOWNLOAD RISKGUARD FACT SHEET

TRUSTED PARTNER

Offers access to genetic counseling and world-class customer service to physicians, patients, and family members for a smooth experience. For general genetic counseling information call us at 855.669.4579 or click to learn more about genetic counseling services with Genome Medical.

Frequently Asked Questions

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How does a patient’s family get tested?

Regardless of your patient’s result, it is important that they share their genetic test results with biological family members so they are better informed of their cancer risks. If a patient’s family member decides to get the Riskguard test to assess their risk for cancer, they will need to share a copy of your patient’s genetic test results with their healthcare provider.

For more information about genetic testing, family members can speak with their healthcare provider and they can learn more about genetic counseling services with Genome Medical.

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EXACTSCIENCES.COM

You are now leaving Exact Sciences website and are going to a website that is not operated by either Exact Sciences or PreventionGenetics.

Exact Sciences and PreventionGenetics is committed to providers and patients by offering Riskguard™ Hereditary Cancer Test, a 32-gene Next-Generation Sequencing test for those who want to understand their risk of developing inherited forms of cancer, why cancer may be common in their family, and their screening options.

Links to all outside site do not imply a recommendation of a particular provider by Exact Sciences or PreventionGenetics. Exact Sciences and PreventionGenetics accepts no responsibility or liability for the content or services of other websites.

Genetic counseling providers may charge a fee for their services associated with the consultation. Genetic counseling providers operate independently from Exact Sciences and PreventionGenetics. Only orders from licensed healthcare providers are accepted.

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Contact Us

With questions about the test, order form, kits, or patient results call us at 855-669-4579

For general genetic counseling information call us at 855.669.4579 or learn more about genetic counseling services with Genome Medical

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For help navigating the insurance and billing process, see our Billing and Coverage page

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Know your inherited cancer risk so you can be proactive about your health

If you have already been diagnosed with cancer, knowing your inherited cancer risk gives healthcare providers the opportunity for more personalized treatment options. If you have a gene variant known to increase the risk of getting cancer, knowing your risk can guide a more specific cancer screening schedule.

Riskguard can detect gene variants associated with an increase risk for these cancers: breast, prostate, colorectal, ovarian, endometrial, pancreatic, gastric, and melanoma.

Meeting with a genetic counselor before or after your test can help you better understand the implications of your result.

How does testing help my family?

Once a person is found to have a gene variant associated with a higher risk of getting cancer, other biological family members can benefit from that information.

Family members can get the Riskguard test to see if they carry the same variant and better assess their cancer risks. A healthcare provider can guide cancer screening options based on results.

For more information about family testing, you can speak with your healthcare provider or learn more below about genetic counseling services with Genome Medical.

What do the results mean?

Riskguard test results are designed to be simple and easy-to-understand. Speaking with your healthcare provider or genetic counselor can help you better understand your results and what actions you can take.

POSITIVE

A pathogenic gene variant is found. This result does not mean you'll develop cancer. It means your risk for inherited cancer is higher than average. Specific cancer risks depend on gene.

NEGATIVE

A pathogenic gene variant is not found. While your risk for an inherited cancer condition is reduced, your cancer risks should be considered in the context of your personal and family history.

VARIANT OF UNCERTAIN SIGNIFICANCE

At least one genetic variant was found, but it is unclear if this change causes an increased risk for cancer or if it’s harmless.

Download a sample patient report

How does the testing process work?

STEP 1.

SPECIMEN COLLECTION

A blood, saliva, or buccal sample is taken and sent to the lab at PreventionGenetics for genetic analysis.

STEP 2.

PRIOR AUTHORIZATION

If required by your insurance, we will contact your health plan to request coverage for testing. In some cases, your healthcare provider may request that you speak with a genetic counselor prior to testing.

STEP 3.

LAB ANALYSIS

The hereditary cancer test is performed, and results will be sent to your doctor.

STEP 4.

TEST RESULT CONSULTATION

Your healthcare provider will review the Riskguard test results with you. Your healthcare provider may request that you speak with a Genetic Counselor to discuss your results and answer any questions you may have about your family members being tested.

Frequently Asked Questions

Who is the Riskguard test appropriate for? Who should not use the test?

The Riskguard test can be used for people with clinical features of a cancer syndrome or a family history of cancer. Clinical features or family history includes early-onset cancer or certain types of cancer, multiple primary cancers, multiple family members (blood relatives) with cancer, and people of Ashkenazi descent with a concern for cancer. This test is specifically designed for inherited (germline) mutations. It is not appropriate for the detection of somatic mutations in tumor tissue.
Where can I find resources about genetic counseling?
What if my insurance requires genetic counseling?

In some instances, insurance companies require genetic counseling. Exact Sciences will check insurance for you. We’ll find out if genetic counseling is required for your insurance coverage and, if needed, we offer access to genetic counseling services. For more information about genetic consultation options, call us at 855.669.4579.
How does my family get tested?

Regardless of your result, it is important that you share your genetic test results with biological family members so they are better informed of their cancer risks. If your family member decide to get the Riskguard test to assess their risk for cancer, they will need to share a copy of your genetic test results with their healthcare provider.

For more information about genetic testing, family members can speak with their healthcare provider and they can learn more about genetic counseling services with Genome Medical.

YOU ARE NOW LEAVING
EXACTSCIENCES.COM

You are now leaving Exact Sciences website and are going to a website that is not operated by either Exact Sciences or PreventionGenetics.

Exact Sciences and PreventionGenetics is committed to providers and patients by offering Riskguard™ Hereditary Cancer Test, a 32-gene Next-Generation Sequencing test for those who want to understand their risk of developing inherited forms of cancer, why cancer may be common in their family, and their screening options.

Links to all outside site do not imply a recommendation of a particular provider by Exact Sciences or PreventionGenetics. Exact Sciences and PreventionGenetics accepts no responsibility or liability for the content or services of other websites.

Genetic counseling providers may charge a fee for their services associated with the consultation. Genetic counseling providers operate independently from Exact Sciences and PreventionGenetics. Only orders from licensed healthcare providers are accepted.

CONTINUE TO GENOME MEDICAL

Contact Us

With questions about your test result and to speak with a genetic counselor call us at 855-669-4579

For general genetic counseling information call us at 855.669.4579 or learn more about genetic counseling services with Genome Medical

LEARN MORE

For help navigating the insurance and billing process, obtaining prior authorizations, flexible payment options, and more

Learn more

References

1. Full coverage is defined as 297M lives. Data from AIS Director of Health Plans.

2. Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. V2.2022 and Genetic/Familial High-Risk Assessment: Colorectal Cancer. V2.2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed August 1, 2022. To view the most recent and complete version of the guidelines, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.

3. Data on File.

*Fee-for service Medicaid patients may still owe a copay depending on their state plan.

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