The Riskguard™ test is the knowledge that gives you power over your health

The Riskguard™ test is an assessment tool that can help uncover hereditary cancer risk. With just a simple blood or saliva sample, it checks for hereditary genetic changes that can cause an increased risk for certain cancers.

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Who can the Riskguard test help?

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If you have a family history of cancer, the Riskguard test can help you know if you have inherited changes in your genes that are linked to cancer, and may inform risk-reducing strategies.

If you have been diagnosed with cancer, the Riskguard test can help you know about hereditary genetic changes in your genes that can assist you and your provider in making a treatment path customized to you.

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How can the Riskguard test help?

Tailored treatment and prevention journeys

Have peace of mind knowing you and your provider can form better treatment and prevention journeys guided by genetics.1-6

Active gene monitoring and ongoing follow up

Take comfort in knowing we constantly monitor genetic research and we will proactively reach out with new clinically relevant results.

Easy-to-understand results

Receive easy-to-understand results with potential next steps for a personalized care plan.

We work hard to make understanding results easy

Sometimes receiving results can be complicated. That’s why we’ve made our results easy to understand, and our dedicated support team will be here every step of the way to walk you through the process.

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A negative result means you’ll have powerful information.

Knowing your result is negative may do more than put you at ease, it could also mean less frequent screenings and avoiding unnecessary treatment.7-9 You and your provider can use this information, along with your family history and other factors, to decide next steps.

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A positive result does not mean you’ll develop cancer.

It means you may be at a higher risk than average, and we’re here to support you and your provider as you create a personalized prevention or treatment plan. We’ll also let you know about future changes to your results or new research that could optimize your care path.

Ongoing genetic monitoring and follow-up

We’ll keep you in the know.

We’ll reach out with updates that impact you after testing. Once you get your Riskguard test results, we’ll continue to monitor genetic research for critical changes. Basically, when experts discover new science that affects your genes, your cancer risk, or your treatment, we’ll let you know.*

Proactive updates and outreach

Notifications if your cancer risk changes

Data about your genes that includes an action plan

New guidelines and screening recommendations

Cutting-edge treatment options

Riskguard checks for genes across 10 cancer types

Colorectal, Breast, Prostate, Pancreatic, Ovarian, Endometrial, Skin, Gastric, Kidney, Endocrine
Colorectal, Breast, Prostate, Pancreatic, Ovarian, Endometrial, Skin, Gastric, Kidney, Endocrine

Not all questions have to mean an office visit

Our premium customer service is just a phone call away, and we can answer questions big and small before, during, and after testing.

On-Demand Customer Care

Call our customer care team at 1-866-662-6897 with general questions about the Riskguard test, billing, insurance coverage, and flexible payment plans.

Call Customer Care 

Genetic Counselors

Ask customer care to connect you with an independent genetic counselor for an in-depth telehealth consult. They can help review your family history, assess your cancer risk, understand your Riskguard test results, and assist with next steps.

How it works

See if the Riskguard test is a fit

Talk with your provider to determine if it’s the right fit for you. Our customer care team can help answer questions you may have about the Riskguard test.

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Take the test

The Riskguard test will need to be ordered by your provider and performed in-office. We offer blood and saliva test kits, so you and your provider can choose what’s best.

Get your results

Your provider will review your results with you and design a customized plan. For help understanding your results or exploring your care options, we can connect you to a genetic counselor.

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You have enough things to worry about, insurance coverage shouldn’t be one of them.

Coverage for eligible patients including Medicare and commercial insurance

Specialized support for billing insurance and prior authorization

Flexible payment options

View Billing and Coverage 

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With questions about ordering the Riskguard test, insurance billing and payment options, checking results, or getting connected with a genetic counselor, call us at 1-866-662-6897 or email us at

*The terms of this product offering are subject to change and not offered permanently or in perpetuity. Any modifications are to be considered effective once published on this website

An independent genetic counselor may charge a fee for their services.

Data on file

The Exact Sciences Riskguard test was developed, and its performance characteristics validated by an Exact Sciences laboratory following College of American Pathologists (CAP) and Clinical Laboratory Improvement Amendments (CLIA) regulations. The test is performed in Marshfield, WI at PreventionGenetics LLC, a wholly owned subsidiary of Exact Sciences. PreventionGenetics is accredited by CAP, certified under CLIA regulations, and qualified to perform high-complexity clinical laboratory testing. It has not been cleared or approved by the US Food and Drug Administration or other notified regulatory authority.