New Noninvasive Colorectal Cancer Test Shows Promise

• Screening test measures DNA changes in three genes and detects occult blood.
• Test shows 83 percent sensitivity for precancer with high-grade dysplasia.

ANAHEIM, CA. –  A new noninvasive test for colorectal cancer screening demonstrated high sensitivity for detecting colorectal cancer, in particular precancers that are most likely to develop into cancer, according to data presented at the 11th Annual AACR International Conference on Frontiers in Cancer Prevention Research, held here Oct. 16-19, 2012.

"This test measures different kinds of DNA changes, known as methylation and mutation, along with a measure of fecal blood. By combining these measures, we can look for the kinds of biological changes that are most frequently found in precancers and cancers in the colon," said Graham P. Lidgard, Ph.D., senior vice president of research and development and chief science officer at Exact Sciences, which developed the test and sponsored the study.

Lidgard and colleagues analyzed 1,003 patient samples from 36 study sites and developed an analytic algorithm for the novel, automated stool DNA-based test platform, which generated a positive or negative result for each patient. The specimens were collected either before colonoscopy bowel preparation in screening and surveillance patients or at least seven days post-colonoscopy from patients with colorectal cancer and large precancers.

The control group included 796 patients with negative colonoscopies or small polyps (less than 1 cm), and the case group included 207 patients with confirmed colorectal cancer or precancers.

"By analyzing samples with confirmed diagnoses from colonoscopy, we were able to build an analytic algorithm that combines our 11 stool-based biomarkers into a single result," Lidgard said. "Through this study, we were able to demonstrate a high detection rate for both cancers and precancers using our automated analytic platform and algorithm."

The researchers reported that the test detected 98 percent of all cancers as well as 83 percent of precursors with high-grade dysplasia and 57 percent of precursors 1 cm or larger overall, at 90 percent nominal specificity.

"We are encouraged by the results of this study for detecting cancer and cancer precursors, especially the precursor lesions with high-grade dysplasia, an abnormality broadly recognized as being associated with a higher risk for progression to cancer itself," Lidgard said. "Current screening tests using only fecal occult blood are biologically limited in their ability to detect precursors to colorectal cancer."

Exact Sciences is involved in a large colorectal cancer screening study collecting samples from more than 10,000 patients prior to screening colonoscopy. The company plans to apply for FDA approval after completing the study.

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Founded in 1907, the American Association for Cancer Research (AACR) is the world's first and largest professional organization dedicated to advancing cancer research and its mission to prevent and cure cancer. AACR membership includes more than 34,000 laboratory, translational and clinical researchers; population scientists; other health care professionals; and cancer advocates residing in more than 90 countries. The AACR marshals the full spectrum of expertise of the cancer community to accelerate progress in the prevention, biology, diagnosis and treatment of cancer by annually convening more than 20 conferences and educational workshops, the largest of which is the AACR Annual Meeting with more than 17,000 attendees. In addition, the AACR publishes seven peer-reviewed scientific journals and a magazine for cancer survivors, patients and their caregivers. The AACR funds meritorious research directly as well as in cooperation with numerous cancer organizations. As the scientific partner of Stand Up To Cancer, the AACR provides expert peer review, grants administration and scientific oversight of team science and individual grants in cancer research that have the potential for near-term patient benefit. The AACR actively communicates with legislators and policymakers about the value of cancer research and related biomedical science in saving lives from cancer.

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