Exact Sciences Introduces the Oncotype MAP™ Pan-Cancer Tissue Test to Help Guide Treatment for Patients with Advanced Cancer

Comprehensive genomic profiling panel aids therapy selection decisions for a breadth of solid tumor types

MADISON, Wis., October 12, 2020 – Exact Sciences Corp. (NASDAQ: EXAS) today announced the introduction of the Oncotype MAP™ Pan-Cancer Tissue test for patients with advanced, metastatic, refractory, or recurrent cancer. The Oncotype MAP test, previously known as PCDx, provides clinically actionable information from genomic alterations in hundreds of cancer-related genes, allowing physicians to understand a patient’s tumor profile and effectively recommend targeted therapies or clinical trials.

“Exact Sciences is pursuing life-changing answers that give people the clarity to take action earlier. Our growing Precision Oncology portfolio and the addition of the Oncotype MAP test allow us to do just that for patients fighting late-stage or metastatic cancer,” said Kevin Conroy, chairman and CEO of Exact Sciences. “Patients with advanced cancer need answers fast, and providing them with actionable results in days, rather than weeks, is critical for improving their outcomes.”

Key attributes and differentiators of the Oncotype MAP test include:

  • fast turnaround time of 3-5 business days[1],[2] to guide timely treatment decisions,
  • small sample requirements with as little as 3 mm2 of tissue or 2-3 slides[3],
  • highly accurate[1] and comprehensive results using next generation sequencing and immunohistochemistry, and,
  • based on a study from a previous generation of the test, a significantly increased rate of progression-free survival when compared to patients who did not utilize the test (43% vs. 5%)[4].

The Oncotype MAP test report is easy to interpret with NCCN® Compendium-based recommendations, along with potential evidence-based therapies and clinical trials. The report is currently tailored to support clinical decision making by showing actionable biomarkers associated with more than 100 evidence-based therapies, over 45 combination therapies, and more than 650 active clinical trial associations. By delivering insights into targeted therapy options, the Oncotype MAP test is designed to address the needs of more than 500,000 patients who face advanced cancer each year in the United States[5].

“The systemic treatment of patients with advanced or metastatic cancer is challenging,” said Rick Baehner, MD, chief medical officer of Precision Oncology at Exact Sciences. “Oncotype MAP is a tissue-based assay which delivers results regarding the underlying biology of a patient’s cancer and provides therapeutic and clinical trial options. Genomic results guide clinicians to individualize and optimize oncology therapy by targeting patient tumor biology with the most effective therapies.”

The Oncotype MAP test is currently available for physicians in the U.S. to order at www.OncotypeMAP.com. Medicare covers the Oncotype MAP test for qualifying members and commercial coverage varies by insurance plan and patient benefit level.

About the Oncotype MAPPan-Cancer Tissue Test
The Oncotype MAPTM Pan-Cancer Tissue test is a rapid, comprehensive tumor profiling panel that aids therapy selection for patients with advanced, metastatic, refractory, or recurrent cancer. With minimal tissue requirements, the Oncotype MAP test utilizes next generation sequencing (NGS) and immunohistochemistry (IHC) to provide in-depth insights into genomic alterations in hundreds of cancer-related genes, including tumor mutations, copy number variants, fusions, tumor mutation burden (TMB), microsatellite instability, and protein expression. Providing results in 3-5 business days[1],[2], the Oncotype MAP test report is currently tailored to support clinical decision making with actionable biomarkers associated with more than 100 evidence-based therapies, over 45 combination therapies, and more than 650 active clinical trial associations, to deliver treatment options for a breadth of solid tumor types. The Oncotype MAP test is performed in a laboratory certified under the Clinical Laboratory Improvement Amendments (CLIA) and accredited by the College of American Pathologists (CAP). To learn more about the Oncotype MAP test, visit www.OncotypeMAP.com.

About Exact Sciences Corp.

A leading provider of cancer screening and diagnostic tests, Exact Sciences relentlessly pursues smarter solutions providing the clarity to take life-changing action, earlier. Building on the success of the Cologuard® and Oncotype DX® tests, Exact Sciences is investing in its product pipeline to take on some of the deadliest cancers and improve patient care. Exact Sciences unites visionary collaborators to help advance the fight against cancer. For more information, please visit the company’s website at www.exactsciences.com, follow Exact Sciences on Twitter @ExactSciences, or find Exact Sciences on Facebook.

NOTE: Oncotype DX, Oncotype MAP and Oncotype MAP Pan-Cancer Tissue are trademarks of Genomic Health, Inc. Cologuard is a trademark of Exact Sciences Corporation.


Media: Stephanie Spanos,  sspanos@exactsciences.com, 608-556-4380       

Investors: Megan Jones, meganjones@exactsciences.com, 608-535-8815

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We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

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1 Data on file, in-house assay optimization protected by trade-secret/patent regulations.

2 Turnaround time is based on sample receipt.

3 Morris S, Subramanian J, Gel E, Runger G, Thompson E, Mallery D, et al. Performance of next-generation sequencing on small tumor specimens and/or low tumor content samples using a commercially available platform. PLoS ONE. (2018); 13(4): e0196556. https://doi.org/ 10.1371/journal.pone.0196556.

4 Radovich, M, et al. Clinical benefit of a precision medicine-based approach for guiding treatment of refractory cancers. Oncotarget. (2016); 7(35): 56491-56500. https://doi.org/ 10.18632/oncotarget.10606.

5 L.E.K. Analysis of NIH SEER Program (2016). ASCO 2020 Poster #184919 from Roche

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