Exact Sciences Honored as 2016 BIG Award Company of the Year in Health Care

Annual Business Intelligence Group (BIG) awards recognize industry leadership and performance

MADISON, Wis., Oct. 6, 2016 – Exact Sciences Corp. (Nasdaq: EXAS) today announced that the company received the Business Intelligence Group’s 2016 Company of the Year BIG Award for Business in the Health Care category.

The BIG Awards were launched in 2012 to recognize and reward companies, products and people that are leading their respective industries, as judged by business executives.

“We are honored to receive this year’s BIG Award, which recognizes the tireless efforts of our entire team to develop Cologuard and position it to become a standard of care in colon cancer screening,” said Kevin Conroy, chairman and CEO of Exact Sciences. “Since inception, we have focused on a single goal: helping win the war on cancer through early detection. Cologuard represents an important step toward reaching that goal. Thank you to the judges and the Business Intelligence Group for this recognition and congratulations to our fellow recipients for their achievements.”

In 2014, following nearly 20 years of research and development, Exact Sciences launched Cologuard®, the first and only FDA-approved, stool DNA-based screening test for adults 50 and older who are at average risk for colorectal cancer. Colon cancer is considered one of the most preventable cancers because of the extended period of time for precancer to develop into cancer. However, it’s also considered one of the least prevented cancers because more than 41 percent of Americans ages 50-75 are unscreened. Since FDA approval of Cologuard, Exact Sciences remains focused on increasing the colon cancer screening population by expanding patient access to this innovative test.

“The Business Intelligence Group highlights those with vision, creativity and persistence, all hallmarks found in the world’s leading companies and individuals across the globe,” said Russ Fordyce, managing director of the Business Intelligence Group. “Exact Sciences—in its journey to bring to market, drive awareness of and expand access to a game changer in colon cancer screening—exemplifies all of these qualities. We congratulate Exact Sciences and all of this year’s winners, as they are truly a select group.”

About Cologuard
Cologuard was approved by the FDA in August 2014 and results from Exact Sciences' prospective 90-site, point-in-time, 10,000-patient pivotal trial were published in the New England Journal of Medicine in March 2014. Cologuard is included in the recommendations of the U.S. Preventive Services Task Force (2016) and the American Cancer Society’s (2014) colorectal cancer screening guidelines.  Stool DNA is included in the combined screening guidelines of the American Cancer Society/U.S. Multi-Society Task Force/American College of Radiology (2008), the American College of Gastroenterology guidelines (2009) and the National Comprehensive Cancer Network (2016). Cologuard is indicated to screen adults of either sex, 50 years or older, who are at average risk for colorectal cancer. Cologuard is not for everyone and is not a replacement for diagnostic colonoscopy or surveillance colonoscopy in high-risk individuals. False positives and false negatives do occur. Any positive test result should be followed by a diagnostic colonoscopy. Following a negative result, patients should continue participating in a screening program at an interval and with a method appropriate for the individual patient. Cologuard performance when used for repeat testing has not been evaluated or established. For more information about Cologuard, visit www.CologuardTest.com. Rx Only.

About Exact Sciences Corp.
Exact Sciences Corp. is a molecular diagnostics company focused on the early detection and prevention of the deadliest forms of cancer. The company has exclusive intellectual property protecting its non-invasive, molecular screening technology for the detection of colorectal cancer. For more information, please visit the company's website at www.exactsciences.com, follow Exact Sciences on Twitter @ExactSciences or find Exact Sciences on Facebook.

About Business Intelligence Group
The Business Intelligence Group was founded with the mission of recognizing true talent and superior performance in the business world. Unlike other industry award programs, business executives—those with experience and knowledge—judge the programs. The organization’s proprietary and unique scoring system selectively measures performance across multiple business domains and then rewards those companies whose achievements stand above those of their peers. For more information, please visit: www.bintelligence.com.

This news release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended that are intended to be covered by the "safe harbor" created by those sections. Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as "believe," "expect," "may," "will," "should," "could," "seek," "intend," "plan," "estimate," "anticipate" or other comparable terms. All statements other than statements of historical facts included in this news release regarding our strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding expected future operating results, anticipated results of our sales and marketing efforts, expectations concerning payor reimbursement and the anticipated results of our product development efforts. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, the following: our ability to successfully and profitably market our products and services; the acceptance of our products and services by patients and healthcare providers; the willingness of health insurance companies and other payors to cover Cologuard and reimburse us for our performance of the Cologuard test; the amount and nature of competition from other cancer screening products and services; the effects of any healthcare reforms, including the Affordable Care Act, or changes in healthcare pricing, coverage and reimbursement; recommendations, guidelines and/or quality metrics issued by various organizations such as the U.S. Preventive Services Task Force, the American Cancer Society and the National Committee for Quality Assurance regarding cancer screening or our products and services; our ability to successfully develop new products and services; our success establishing and maintaining collaborative, licensing and supplier arrangements; our ability to maintain regulatory approvals and comply with applicable regulations; and the other risks and uncertainties described in the Risk Factors and in Management’s Discussion and Analysis of Financial Condition and Results of Operations sections of our most recently filed Annual Report on Form 10-K and our subsequently filed Quarterly Report(s) on Form 10-Q. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.


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