1995	Exact Sciences is founded.
February 2001	Exact Sciences holds Initial Public Offering.
March 2008	American Cancer Society includes multi-target stool DNA testing in colorectal cancer screening guidelines.
March 2009	American College of Gastroenterology includes multi-target stool DNA testing in its colorectal cancer screening guidelines.
April 2009	Kevin Conroy is appointed President and Chief Executive Officer and Maneesh Arora is appointed Chief Financial Officer.
August 4, 2009	Graham Lidgard, PhD is appointed Chief Scientific Officer.
April 19, 2010	Exact Sciences raises $17.6 million in common stock offering.
July 28, 2010	Poster presented at American Association for Clinical Chemistry (AACC) shows Exact Sciences methylation detection achieves 100% sensitivity and specificity in colorectal cancer tissue.
October 28, 2010	Results of Exact Sciences validation study is released at American Association for Cancer Research (AACR) meeting in Philadelphia.
November 10, 2010	Exact Sciences raises $64.7 million in common stock offering.
July 2011	Exact Sciences begins enrollment for the DeeP-C Study, the company’s pivotal clinical trial for colorectal cancer.
November 11, 2011	Exact Sciences presents data from a second validation study at the Association for Molecular Pathology annual meeting in Dallas, Texas.
December 9, 2011	Exact Sciences raises $27.1 million in common stock offering.
August 8, 2012	Exact Sciences raises $50.2 million in common stock offering.
October 18, 2012	Poster presented at American Association for Cancer Research (AACR) Frontiers in Cancer Prevention meeting in Anaheim, California shows Exact Sciences, at a nominal specificity of 90%, achieves sensitivity of 98% in the detection of colorectal cancer and 83% in the detection of high-grade dysplasia, the majority of which progress to cancer.
November 15, 2012	Exact Sciences completes enrollment of DeeP-C clinical study, the largest privately funded study of its kind for colorectal cancer screening, enrolling more than 12,700 subjects.
December 7, 2012	Exact Sciences submits to the U.S. Food and Drug Administration the first module of the premarket approval application for its multi-target stool DNA colorectal cancer screening test.
April 18, 2013	Exact Sciences announces DeeP-C clinical study preliminary top-line results.
March 19, 2014	Results from the DeeP-C pivotal clinical study are published online in the New England Journal of Medicine.
March 27, 2014	The U.S. Food and Drug Administration's (FDA) Molecular and Clinical Genetics Panel of the Medical Devices Advisory Committee determines by a unanimous vote of 10 to zero that Exact Sciences demonstrated safety, effectiveness and a favorable risk benefit profile of Cologuard ®, the company's multi-target stool DNA (sDNA), non-invasive colorectal cancer screening test.
April 3, 2014	Results from the DeeP-C study are published in the New England Journal of Medicine’s April 2014 print issue.
August 11, 2014	The U.S. Food and Drug Administration (FDA) approves Cologuard. Exact Sciences also receives a proposed coverage memorandum from the Centers for Medicare and Medicaid Services (CMS). Cologuard is the first product to take part in the joint FDA and CMS parallel review pilot program in which both agencies simultaneously review medical devices.
October 9, 2014	The Centers for Medicare & Medicaid Services (CMS) issues its final National Coverage Determination (NCD) for Cologuard, making it the first and only Food and Drug Administration (FDA) approved multi-target stool DNA test for the detection of colorectal cancer and precancer covered by Medicare.
November 6, 2014	The American Cancer Society (ACS) guidelines include Cologuard in a recommended list of screening options for colorectal cancer.
February 6, 2015	Exact Sciences Corp. and Mayo Clinic announce a five-year extension and expansion of their collaboration, broadening their efforts to develop screening, surveillance and diagnostic tests beyond colorectal cancer to address other diseases within the gastrointestinal tract.
June 15, 2016	United States Preventive Services Task Force (USPSTF) includes Cologuard in its final colorectal cancer screening recommendations on equal standing among the other included screening tests.
October 3, 2016	Cologuard included in the 2017 Healthcare Effectiveness Data and Information Set (HEDIS) quality measures for colorectal cancer screening. More than 90 percent of America's health plans measure quality based on HEDIS.
October 28, 2016	Cologuard wins Prix Galein Award for Best Medical Technology Product.
March 1, 2017	A study from Exact Sciences and Mayo Clinic released by the American Association of Cancer Research (AACR) shows promise for the development of a blood-based lung cancer test.
April 4, 2017	CMS includes Cologuard in updated Medicare Advantage Star Ratings.
June 23, 2017	Exact Sciences partners with professional golfer Jerry Kelly to promote colorectal cancer screening.
August 16, 2017	The NFL team, the Green Bay Packers, and Cologuard launch a colon cancer awareness campaign.
November 7, 2017	PGA Tour Champions and Exact Sciences announce Cologuard Classic as new title of annual Tucson professional golf tournament.
November 8, 2017	Exact Sciences announces the company will build additional laboratory facilities at 650 Forward Drive on the City of Madison’s west side. Scheduled to open in mid-2019, the facility will create more than 250 jobs over five years as Exact Sciences adds capacity to meet increasing demand for Cologuard.
March 2, 2018	Exact Sciences hosts inaugural Cologuard Classic in Tucson, AZ.
March 19, 2018	Exact Sciences announces launch of New 50 celebrity campaign.